H2N2V1, Main, Exploration, bibRecord, 002701

Variation in nucleotide sequences coding for the N-terminal regions of the matrix and nonstructural proteins of influenza A viruses.

Identifieur interne : 002701 ( Main/Exploration ); précédent : 002700; suivant : 002702

Variation in nucleotide sequences coding for the N-terminal regions of the matrix and nonstructural proteins of influenza A viruses.

Auteurs : R M Hall ; G M Air

Source :

Journal of Virology [ 0022-538X ] ; 1981.

RBID : PMC:171118

Descripteurs français

KwdFr :
- ARN viral (génétique), Antigènes viraux (génétique), Gènes, Mutation, Protéines virales (génétique), Séquence nucléotidique, Variation génétique, Virus de la grippe A (génétique).
MESH :
- génétique : ARN viral, Antigènes viraux, Protéines virales, Virus de la grippe A.
- Gènes, Mutation, Séquence nucléotidique, Variation génétique.

English descriptors

KwdEn :
- Antigens, Viral (genetics), Base Sequence, Genes, Genetic Variation, Influenza A virus (genetics), Mutation, RNA, Viral (genetics), Viral Proteins (genetics).
MESH :
- chemical , genetics : Antigens, Viral, RNA, Viral, Viral Proteins.
- genetics : Influenza A virus.
- Base Sequence, Genes, Genetic Variation, Mutation.

Abstract

Nucleotide sequences have been determined for complementary DNA transcribed from the 3' ends of RNA segments 7 (matrix gene) and 8 (nonstructural gene) from a number of human influenza A viruses isolated over a period of 43 years and representing H0N1, H1N1, H2N2, and H3N2 subtypes. The pattern of nucleotide variation in both genes suggests that RNA segments 7 and 8 were conserved during the reassortment events which were responsible for the antigenic shifts H1N1 leads to H2N2 and H2N2 leads to H3N2. During the 23-year period between the isolation of A/PR/8/34(H0N1) and A/RI/5-/57(H2N2), substitutions have occurred at 7 of 230 nucleotides in RNA segment 7 and 13 of 220 nucleotides in RNA segment 8, and in 20 years A/RI/5-/57(H2N2) to A/Canberra Grammar/77(H3N2) substitutions have occurred at 5 of 230 nucleotides in RNA segment 7 and 12 of 220 nucleotides in RNA segment 8. These give rise to 2 of 67, 5 of 64, 1 of 67, and 5 of 64 amino acid changes, respectively. The number of nucleotide and amino acid changes observed is of the same order of magnitude as that which occurs over a comparable period of drift in RNA segments 4 and 6, which code for the variable antigenic determinants hemagglutinin and neuraminidase.

Images

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC171118

PubMed: 7241645
PubMed Central: 171118

Affiliations:

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<term>Protéines virales</term>
<term>Virus de la grippe A</term>
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<term>Genes</term>
<term>Genetic Variation</term>
<term>Mutation</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Gènes</term>
<term>Mutation</term>
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<front><div type="abstract" xml:lang="en"><p>Nucleotide sequences have been determined for complementary DNA transcribed from the 3' ends of RNA segments 7 (matrix gene) and 8 (nonstructural gene) from a number of human influenza A viruses isolated over a period of 43 years and representing H0N1, H1N1, H2N2, and H3N2 subtypes. The pattern of nucleotide variation in both genes suggests that RNA segments 7 and 8 were conserved during the reassortment events which were responsible for the antigenic shifts H1N1 leads to H2N2 and H2N2 leads to H3N2. During the 23-year period between the isolation of A/PR/8/34(H0N1) and A/RI/5-/57(H2N2), substitutions have occurred at 7 of 230 nucleotides in RNA segment 7 and 13 of 220 nucleotides in RNA segment 8, and in 20 years A/RI/5-/57(H2N2) to A/Canberra Grammar/77(H3N2) substitutions have occurred at 5 of 230 nucleotides in RNA segment 7 and 12 of 220 nucleotides in RNA segment 8. These give rise to 2 of 67, 5 of 64, 1 of 67, and 5 of 64 amino acid changes, respectively. The number of nucleotide and amino acid changes observed is of the same order of magnitude as that which occurs over a comparable period of drift in RNA segments 4 and 6, which code for the variable antigenic determinants hemagglutinin and neuraminidase.</p>
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Variation in nucleotide sequences coding for the N-terminal regions of the matrix and nonstructural proteins of influenza A viruses.

Variation in nucleotide sequences coding for the N-terminal regions of the matrix and nonstructural proteins of influenza A viruses.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration H2N2
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